Zieve’s syndrome:
It is a unique form of hemolytic anaemia (with spur cells and acanthocytes) which can occur in patients with severe alcoholic hepatitis.
Clinical features:
A combination of a tetrad (4):
- Alcoholic hepatitis
- Hemolytic anaemia (with spur cells and acanthocytes)
- Jaundice
- Hyperlipidemia
Treatments:
There is no specific treatment for Zieve's syndrome but supportive therapy is indicated which includes
- Correction of clotting abnormalities
- Treatment of hemolysis
- Treating alcohol withdrawal
- Preventing further alcohol intake
- Adequate nutrition
Source:
- Step Up to MRCP Review Notes for P1 & P2 by Dr Khaled El Magraby 1st Edition; page: 801
- Harrison’s Principles of Internal Medicine 2 volumes 19th Edition; page: 2059
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