What are the causes of culture negative endocarditis?

Causes of Culture negative endocarditis

1. Infective causes 

• Brucella spp.
• Coxiella burnetti 
• Chlamydia spp 
• Prior antibiotic therapy 
• Mycoplasma spp
• Legionella spp 
• Histoplasmosis 
• Tropherema whipelli 
• Fungi 
• HACEK: Hemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella
• Bartonella

2. Non-infective causes:

• SLE (Libmann-Sacs)
• Marantic endocarditis 

[The above picture shows the clinical features of infective endocarditis with a percentage of each feature. Taken from Kumar and Clark's Clinical Medicine 9th Edition: 1021]