What are the causes of simultaneous Lower respiratory tract (LRT) disease and CNS disease?

Causes of simultaneous Lower respiratory tract (LRT) disease and CNS disease: 

A. Infections: 

• HIV 
• TB 
• Legionnaire's disease 
• Mycoplasma pneumonia 
• Streptococcal/staphylococcal pneumonia 
• Malaria 
• Cysticercosis 

B. Malignancy:

• Primary or secondary bronchial carcinoma 

C. Granulomatous disease :

• Sarcoidosis 
• Histiocytosis X 

D. Vasculitides: 

• Polyarteritis nodosa 
• Wegener's granulomatosis 
• SLE 

E. Neuroectodermal syndrome: 

• Neurofibromatosis 
• Tuberose sclerosis 

F. Sickle cell syndrome 

The following image shows the defence mechanism of the Lower Respiratory Tract (LRT):

[The above image is created using the information from Davidsons Principles and Practice of Medicine 23 edition, page: 550]

In the following image, we can find out the causes of meningitis from the clues from history and clinical examinations:

[Image is taken from Kumar & Clark’s Clinical Medicine 9th Edition; Box 21.54]