What are the causes of simultaneous Lower respiratory tract (LRT) disease and CNS disease?

Causes of simultaneous Lower respiratory tract (LRT) disease and CNS disease: 

A. Infections: 
  • HIV 
  • TB 
  • Legionnaire's disease 
  • Mycoplasma pneumonia 
  • Streptococcal/staphylococcal pneumonia 
  • Malaria 
  • Cysticercosis 
B. Malignancy:
  • Primary or secondary bronchial carcinoma 
C. Granulomatous disease :
  • Sarcoidosis 
  • Histiocytosis X 
D. Vasculitides: 
  • Polyarteritis nodosa 
  • Wegener's granulomatosis 
  • SLE 
E. Neuroectodermal syndrome: 
  • Neurofibromatosis 
  • Tuberose sclerosis 
F. Sickle cell syndrome 

The following image shows the defence mechanism of the Lower Respiratory Tract (LRT):

[The above image is created using the information from Davidsons Principles and Practice of Medicine 23 edition, page: 550]

In the following image, we can find out the causes of meningitis from the clues from history and clinical examinations:

[Image is taken from Kumar & Clark’s Clinical Medicine 9th Edition; Box 21.54]

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