What are the causes of Addison's disease (primary hypoadrenalism )?

Causes of Addison's disease (primary hypoadrenalism )


  • Autoimmune adrenalitis
  • TB
  • HIV/AIDS
  • Bilateral adrenalectomy
  • Adrenal haemorrhage or infarction following meningococcal septicemia (Waterhouse-Friedrichson syndrome)
  • Infiltration disorders:
      • Carcinomatous infiltration of adrenal glands (bronchial carcinoma)
      • Haemochromatosis
      • Amyloidosis
      • Granulomatous disorders
  • Lymphoma
  • Metyrapone therapy
  • Schilder's disease ( adrenal leukodystrophy)
  • Wolman's disease (hepatosplenomegaly and steatorrhoea)



Source:
Davidsons Principles and Practice of Medicine 23th edition: 671
Kumar & Clark’s Clinical Medicine 9th edition: 1226

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