What are the Diagnostic criteria for polyarteritis nodosa (PAN)?

Polyarteritis nodosa (PAN):

Diagnostic criteria for polyarteritis nodosa (PAN)


1990 ACR criteria are the following. A patient shall be said to have PAN if at least 3 of the following 10 criteria are present. Considering the presence of 3 or more criteria, the sensitivity of diagnosis is 82.2% and specificity is 86.6%
  1. Weight loss of more than 4 kg
  2. Livedo reticularis
  3. Testicular pain or tenderness
  4. Myalgia, weakness or leg tenderness
  5. Mono/polyneuropathy
  6. Diastolic BP >90 mmHg
  7. HBsAg Positive
  8. Elevated BUN (>40 mg/dl or 14.28 mmol/L) or raised creatinine (>1.5 mg/dl or 132.6 ยตmol/L)
  9. Arteriographic abnormalities (micro-aneurysms)
  10. Positive biopsy of a small or medium-sized artery (non-granulomatous vasculitis)

Source:

  • Kumar & Clark’s Clinical Medicine 9e (2016): 701, 749
  • Davidsons Principles and Practice of Medicine 23 edition: 1042

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