What are the Diagnostic criteria for polyarteritis nodosa (PAN)?

Polyarteritis nodosa (PAN):

Diagnostic criteria for polyarteritis nodosa (PAN)

1990 ACR criteria are the following. A patient shall be said to have PAN if at least 3 of the following 10 criteria are present. Considering the presence of 3 or more criteria, the sensitivity of diagnosis is 82.2% and specificity is 86.6%

1. Weight loss of more than 4 kg
2. Livedo reticularis
3. Testicular pain or tenderness
4. Myalgia, weakness or leg tenderness
5. Mono/polyneuropathy
6. Diastolic BP >90 mmHg
7. HBsAg Positive
8. Elevated BUN (>40 mg/dl or 14.28 mmol/L) or raised creatinine (>1.5 mg/dl or 132.6 µmol/L)
9. Arteriographic abnormalities (micro-aneurysms)
10. Positive biopsy of a small or medium-sized artery (non-granulomatous vasculitis)

Source:

• Kumar & Clark’s Clinical Medicine 9e (2016): 701, 749
• Davidsons Principles and Practice of Medicine 23 edition: 1042