What is Felty’s syndrome?

Felty’s syndrome

Rheumatoid arthritis with splenomegaly and neutropenia is called Felty’s syndrome. 


Felty's syndrome = RA + Splenomegaly + neutropenia 

 Risk factors of Felty’s syndrome:

  • Age of onset 50-70 years
  • Female > male
  • Caucasians > blacks
  • Long-standing RA
  • Deforming but inactive disease
  • Seropositive for Rheumatoid Factor

Clinical features of Felty’s syndrome:

  • Splenomegaly
  • Lymphadenopathy
  • Weight loss
  • Skin pigmentation
  • Keratoconjunctivitis sicca
  • Vasculitis
  • Leg ulcers
  • Recurrent infections
  • Nodules
[Reproduced from Davidson's principles and practice of medicine 23rd; 1025]


From the Taber's Cyclopedic Medical Dictionary 23rd Edition:

  • keratoconjunctivitis: Inflammation of the cornea and the conjunctiva
  • Keratoconjunctivitis sicca: Dryness with hyperemia of the conjunctiva in Sjogren’s syndrome due to an autoimmune-mediated decreased lacrimal function.
  • Sicca: Came from a Latin word Siccus which means "Dry". 

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