What are the diagnostic criteria of Churg-Strauss Syndrome?

Diagnostic criteria of Churg-Strauss Syndrome

American College of Rheumatology 1990 criteria for Churg-Strauss syndrome 

The presence of 4 or more of the manifestations below is highly indicative of Churg-Strauss syndrome:
  • Asthma
  • Eosinophilia (10% on WCC differential)
  • Mononeuropathy or polyneuropathy
  • Migratory or transient pulmonary infiltrates
  • Systemic vasculitis (cardiac, renal, hepatic)
  • Extravascular eosinophils on a biopsy including artery, arteriole or venule.

From the Taber's Cyclopedic Medical Dictionary 23rd Edition 2017:

  • Adult-onset asthma:  Asthma that begins after age 16, typically as a result of exposure to environmental pollution, occupational antigens, or tobacco smoke.
  • Bakers’ asthma:  A colloquial term for asthma caused by inhalation of airborne wheat proteins in occupational settings.
  • Bronchial asthma: A common form of asthma due to hypersensitivity to an allergen. It is also called allergic asthma.
  • Cardiac asthma: Asthma that results from heart disease, especially due to acute or chronic heart failure.
  • Exercise-induced asthma: Asthma that occurs during physical exertion.
  • Extrinsic asthma: Asthma triggered by an allergic (hypersensitivity) response to an antigen.
  • Intrinsic asthma: It is thought to be due to some endogenous cause. Unlike extrinsic one, no external cause is found.
  • Irritant-induced asthma: Asthma due to exposure to substances that inflame the airways or make them hyperreactive but without inducing an allergic reaction.
  • Nocturnal asthma: In asthmatic patient, the symptoms increases during the sleep.
  • Occupational asthma: Asthma resulting from exposures in the workplace to environmental dust, fibres, gases, smoke, sprays, or vapours.
  • Stable asthma: When has been no increase in symptoms at least in the past four weeks. Or, no need for additional medication for the same time period.
  • Unstable asthma: An increase in the symptoms during the past four weeks.

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