What is Liddles Syndrome?

Liddle’s Syndrome:

Liddle’s Syndrome is an autosomal dominant disorder that mimics hyperaldosteronism, resulting in Hypokalemia associated with hypertension. 

Pathogenesis of Liddle’s syndrome:

It is due to deletional mutation of the amiloride-sensitive ENaC (epithelial Sodium channel) resulting in unregulated sodium absorption by overactive ENaC in the late distal collecting tubule/ cortical collecting duct.

Clinical features and laboratory findings of Liddle’s syndrome:

• Hypertension (due to volume expansion as well as excessive sodium retention)
• Hypernatremia
• Hypokalemia
• Alkalosis
• Decrease renin
• Decrease aldosterone

Liddle’s syndrome= Hypokalemia + Hypertension

Treatment of Liddle’s syndrome:

• Sodium restriction
• Amiloride or triamterene: Both are a potassium-sparing diuretic, though another member of this group i.e. spironolactone is ineffective in this case