What are the causes of culture negative endocarditis?

Causes of Culture negative endocarditis

1. Infective causes 

  • Brucella spp.
  • Coxiella burnetti 
  • Chlamydia spp 
  • Prior antibiotic therapy 
  • Mycoplasma spp
  • Legionella spp 
  • Histoplasmosis 
  • Tropherema whipelli 
  • Fungi 
  • HACEK: Hemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella
  • Bartonella

2. Non-infective causes 


  • SLE (Libmann-Sacs)
  • Marantic endocarditis 
The above picture shows clinical features of infective endocarditis with percentage of each feature. Taken from Kumar and Clark's Clinical Medicine 9th Edition: 1021

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